Charge-dependent anisotropic flow in high-energy heavy-ion collisions from relativistic resistive magneto-hydrodynamic expansion

We have investigated the charge-dependent anisotropic flow in high-energy heavy-ion collisions, using relativistic resistive magneto-hydrodynamics (RRMHD). We consider the optical Glauber model as an initial model of the quark-gluon plasma (QGP) and the solution of the Maxwell equations with source term of the charged particles in two colliding nuclei as initial electromagnetic fields. The RRMHD simulation is performed with these initial conditions in Au-Au and Cu-Au collisions at $\sqrt{s_{\mathrm{NN}}} = 200$ GeV. We have calculated the charge-odd contribution to the directed flow $\Delta v_1$ and elliptic flow $\Delta v_2$ in both collisions based on electric charge distributions as a consequence of RRMHD. Our results show that the $\Delta v_1$ and $\Delta v_2$ are approximately proportional to the electrical conductivity ($\sigma$) of the medium. In the $\sigma=0.023~\mathrm{fm}^{-1}$ case, our result of $\Delta v_1$ is consistent with STAR data in Au-Au collisions. Furthermore, in Cu-Au collisions, $\Delta v_1$ has a non-zero value at $\eta = 0$. We conclude that the charge-dependent anisotropic flow is a good probe to extract the electrical conductivity of the QGP medium in high-energy heavy-ion experiments.Comment: 10 pages, 9 figure

Relativistic resistive magneto-hydrodynamics code for high-energy heavy-ion collisions

We construct a relativistic resistive magneto-hydrodynamic (RRMHD) numerical simulation code for high-energy heavy-ion collisions. We split the system of differential equations into two parts, a non-stiff and a stiff part. For the non-stiff part, we evaluate the numerical flux using HLL approximated Riemann solver and execute the time integration by the second-order of Runge-Kutta algorithm. For the stiff part, which appears in Ampere's law, we integrate the equations using semi-analytic solutions of the electric field. We employ the generalized Lagrange multiplier method to ensure the divergence-free constraint for the magnetic field and Gauss's law. We confirm that our code reproduces well the results of standard RRMHD tests in the Cartesian coordinates. In the Milne coordinates, the code with high conductivity is validated against relativistic ideal MHD tests. We also verify the semi-analytic solutions of the accelerating longitudinal expansion of relativistic resistive magneto-hydrodynamics in high-energy heavy-ion collisions in a comparison with our numerical result. Our numerical code reproduces these solutions.Comment: 16 pages, 14 figure

A CONCEPT FOR PREPAREDNESS AGAINST LEVEL 2 DISASTER RISK

The Japan Society of Civil Engineers proposed to introduce the earthquake motion of level 2 to reflect the seismic forces of the Great Hanshin-Awaji Earthquake in 1995. After the Great East Japan Earthquake in 2011, the undertaking of “human based” soft measures for evacuation in the case of tsunamis that exceed the conventionally assumed scale of level 1 was discussed; design methods that allow facilities to withstand tsunamis in addition to conventional seismic forces are in demand. The level 2 disasters experienced in Japan were incorporated into design concepts only after such large disasters occurred. However, actual level 2 disasters include events other than earthquakes and tsunamis. Increasing seawater temperature due to global warming will induce sea level rise, and typhoons will likely become larger in scale. Disastrous events that exceed conventional design conditions in high tides are more likely to occur. The three largest bay regions in Japan, where large hinterlands lie below sea level, require examination to clarify these risks. The authors reviewed various phenomena and present that risk management on the basis of level 2 disaster risks is of great importance

Retroperitoneal hemorrhage with COVID-19

Introduction: Early prophylactic administration of anticoagulants is recommended in patients with coronavirus disease 2019 (COVID-19). A case of retroperitoneal hemorrhage during inpatient treatment for COVID-19 is reported. Case Presentation : A 69-year-old man was diagnosed with COVID-19 6 days after symptom onset. After admission for difficulty of breathing, he was treated with steroid pulse therapy, remdesivir, and heparin sodium. On day 16 after admission, his hemoglobin and blood pressure dropped. Computed tomography showed a left retroperitoneal hematoma and multiple areas of extravasation in bilateral iliopsoas muscles. Anticoagulation therapy was stopped, and blood transfusion therapy was chosen by considering poor general condition caused by severe pneumonia. On day 19, the hemoglobin and blood pressure improved, and blood transfusion was stopped. However, he died on day 25 due to pneumonia. Conclusion : When retroperitoneal hemorrhage occurs as a complication of COVID-19, appropriate treatment decision, transcatheter arterial embolization or conservative treatment, should be chosen based on patient’s condition

Significant response of sunitinib for RCC

Introduction: A case of multiple liver metastases of clear cell RCC with a significant response to sunitinib as the fifth line after nivolumab is reported. Case presentation: The patient was a 65-year-old man who underwent open nephrectomy for RCC. After the nephrectomy, he had recurrences several times, and metastasectomy had been performed for each recurrence. At 13 years after the nephrectomy, multiple liver, and lung metastases appeared. The treatment was switched to axitinib, followed by cabozantinib, then nivolumab. The best response was PR, SD, and PD for these three drugs, and treatment duration was 14, 3, and 3 months, respectively. As the fifth line, sunitinib was administered, with significant shrinkage of the multiple liver metastases, and PR has been maintained for 34 months. Conclusion: Sunitinib after an IO-drug showed a significant effect in spite of only slight efficacy with other VEGFR-TKIs, which may have occurred through the alteration of the immunological microenvironment

Living donor liver transplantation using sensitized lymphocytotoxic crossmatch positive graft

We describe a successful living donor liver transplantation (LDLT) using a lymphocytotoxic crossmatch highly positive graft. A 41-year-old woman with alcoholic liver cirrhosis was referred as a potential candidate for LDLT, and her husband was willing to donate his partial liver. As the T-lymphocytotoxic crossmatch titer was over 10,000×, the patient was first infused with rituximab for preoperative desensitization, and then five rounds of plasmapheresis were performed. After the third plasmapheresis, the lymphocytotoxic crossmatch test was negative. A left liver graft including the caudate lobe was implanted, and anti-CD25 antibody (basiliximab) was administered on postoperative days 1 and 4. The postoperative course was uneventful except for an episode of mild acute cellular rejection on postoperative day 27. Although the impact of a lymphocytotoxic crossmatch-positive liver graft on acute cellular rejection and graft survival in LDLT remains controversial, perioperative desensitization may provide benefits when using a highly sensitized liver graft

TDP-43 stabilises the processing intermediates of mitochondrial transcripts

The 43-kDa trans-activating response region DNA-binding protein 43 (TDP-43) is a product of a causative gene for amyotrophic lateral sclerosis (ALS). Despite of accumulating evidence that mitochondrial dysfunction underlies the pathogenesis of TDP-43–related ALS, the roles of wild-type TDP-43 in mitochondria are unknown. Here, we show that the small TDP-43 population present in mitochondria binds directly to a subset of mitochondrial tRNAs and precursor RNA encoded in L-strand mtDNA. Upregulated expression of TDP-43 stabilised the processing intermediates of mitochondrial polycistronic transcripts and their products including the components of electron transport and 16S mt-rRNA, similar to the phenotype observed in cells deficient for mitochondrial RNase P. Conversely, TDP-43 deficiency reduced the population of processing intermediates and impaired mitochondrial function. We propose that TDP-43 has a novel role in maintaining mitochondrial homeostasis by regulating the processing of mitochondrial transcripts

Effective Appendix Stump Closure Using the Doubleshanked Titanium Ligation Clip (DS Clip): A Case Report

Background: During laparoscopic appendectomy, several methods and devices can be used to close the appendicular stump, such as endoloops, linear staplers, clips, and open purse-string sutures. The Double-shanked Titanium Ligation Clip® (DS clip; B. Braun Aesculap, Tuttlinger, Germany), a new device that can be used to close the appendicular stump, was approved for use in Japan in March 2015. We report a case of effective appendix stump closure using DS clips. Case presentation: An 81-year-old man was admitted to our hospital with complaints of severe pain in the right lower quadrant of the abdomen. Abdominal contrast-enhanced computed tomography showed a thickened appendix (1.7 cm in diameter) with fecal stones, while acute inflammatory signs were visible around the appendix. He was diagnosed with acute appendicitis for which laparoscopic appendectomy was performed with a curative intent. It was difficult to mobilize the cecum because of inflammation, so we attempted to use DS clips instead of linear staplers. A histological examination revealed gangrenous appendicitis. The patient’s postoperative course was uneventful and he was discharged 10 days postoperatively. We also used DS clips to close the appendicular stump in 12 other cases. We observed no intra- or postoperative complications and no cases of mortality. Conclusion: The management of an appendicular stump using DS clips during laparoscopic appendectomy was simple, safe, and cost-effective. DS clips may be an alternative method to linear staplers

A Rare Case Oesophageal Perforation by a Fish Bone, Leading to Pericardial Penetration and Cardiac Tamponade

An 82-year-old woman swallowed a fish bone and presented to our hospital 3 days later when she had breathing difficulty and became hypotensive. Chest computed tomography (CT) showed a linear structure with high bone density extending from the oesophagus into the pericardium, along with pericardial effusion, air, and a left pleural effusion. We diagnosed the patient with oesophageal perforation by a foreign body (a fish bone) leading to pericardial penetration, cardiac tamponade, and left empyema. The patient underwent emergency surgery. Pericardial fenestration and drainage of the pericardial and thoracic cavities were performed. Chest CT showed a recurrent abscess cavity in the pericardium on day 6. A pigtail catheter was placed in the recurrent abscess cavity under CT guidance for drainage. The patient gradually improved and was discharged after 5 months

CIPRO 2.5: Ciona intestinalis protein database, a unique integrated repository of large-scale omics data, bioinformatic analyses and curated annotation, with user rating and reviewing functionality

The Ciona intestinalis protein database (CIPRO) is an integrated protein database for the tunicate species C. intestinalis. The database is unique in two respects: first, because of its phylogenetic position, Ciona is suitable model for understanding vertebrate evolution; and second, the database includes original large-scale transcriptomic and proteomic data. Ciona intestinalis has also been a favorite of developmental biologists. Therefore, large amounts of data exist on its development and morphology, along with a recent genome sequence and gene expression data. The CIPRO database is aimed at collecting those published data as well as providing unique information from unpublished experimental data, such as 3D expression profiling, 2D-PAGE and mass spectrometry-based large-scale analyses at various developmental stages, curated annotation data and various bioinformatic data, to facilitate research in diverse areas, including developmental, comparative and evolutionary biology. For medical and evolutionary research, homologs in humans and major model organisms are intentionally included. The current database is based on a recently developed KH model containing 36 034 unique sequences, but for higher usability it covers 89 683 all known and predicted proteins from all gene models for this species. Of these sequences, more than 10 000 proteins have been manually annotated. Furthermore, to establish a community-supported protein database, these annotations are open to evaluation by users through the CIPRO website. CIPRO 2.5 is freely accessible at http://cipro.ibio.jp/2.5